In Situ Single-Pass Intestinal Perfusion in Rats for Intestinal Permeability Investigation of Drugs.
W Huang, S Chen, L Sun, H Wang… - Indian Journal of …, 2023 - search.ebscohost.com
… in situ single-pass intestinal perfusion method in rats for intestinal permeability investigation
… In this work, the predicted Fabs of metformin and ranitidine using above-mentioned equation …
… In this work, the predicted Fabs of metformin and ranitidine using above-mentioned equation …
[HTML][HTML] Optimized in silico modeling of drug absorption after gastric bypass: The case of metformin
A Dahan, D Porat, M Markovic, M Zur, O Kister… - Pharmaceutics, 2021 - mdpi.com
… region-dependent permeability of metformin, using the rat single-pass intestinal perfusion
method (… The weight but also the disease burden have an impact on intestinal permeability and …
method (… The weight but also the disease burden have an impact on intestinal permeability and …
Investigating drug absorption from the colon: Single-pass vs. Doluisio approaches to in-situ rat large-intestinal perfusion
I Lozoya-Agullo, M Zur, N Fine-Shamir… - International journal of …, 2017 - Elsevier
… colon permeability data obtained using two different rat perfusion methods the single-pass
intestinal perfusion (SPIP) approach and the closed-loop (Doluisio) perfusion model. A list of …
intestinal perfusion (SPIP) approach and the closed-loop (Doluisio) perfusion model. A list of …
Closed-loop doluisio (colon, small intestine) and single-pass intestinal perfusion (colon, jejunum) in rat—biophysical model and predictions based on Caco-2
I Lozoya-Agullo, I Gonzalez-Alvarez, M Zur… - Pharmaceutical …, 2018 - Springer
… between human and rat small intestine permeability (r 2 … Nevertheless, the rat perfusion data
used in this study were … permeability observed value is closer to the diffusional component. …
used in this study were … permeability observed value is closer to the diffusional component. …
Absorption Properties of Luteolin and Apigenin in Genkwa Flos Using In Situ Single-Pass Intestinal Perfusion System in the Rat
X He, ZJ Song, CP Jiang, CF Zhang - The American journal of …, 2017 - World Scientific
… The aim of this study was to investigate the intestinal absorption mechanisms of Genkwa Flos
… Intestinal permeability of metformin using single-pass intestinal perfusion in rats. World J. …
… Intestinal permeability of metformin using single-pass intestinal perfusion in rats. World J. …
[PDF][PDF] … and validation of a RP-HPLC method for simultaneous determination of metformin hydrochloride, phenol red and metoprolol tartrate for intestinal perfusion …
T Gulsun, S Sahin - Lat. Am. J. Pharm, 2016 - researchgate.net
… perfused single pass rat intestinal perfusion preparation. … for metformin hydrochloride
increased in the order of ileum > colon > jejunum, whereas estimated intestinal permeability values …
increased in the order of ileum > colon > jejunum, whereas estimated intestinal permeability values …
Rat intestinal drug permeability: A status report and summary of repeated determinations
… intestinal permeability data. The rat single-pass intestinal perfusion (SPIP) and intestinal …
and evaluate all the available intestinal permeability data for drugs that have been obtained …
and evaluate all the available intestinal permeability data for drugs that have been obtained …
[HTML][HTML] Meta-assessment of metformin absorption and disposition pharmacokinetics in nine species
YS Jeong, WJ Jusko - Pharmaceuticals, 2021 - mdpi.com
… Therefore, expecting that intestinal permeability is the major determinant … a single-pass
intestinal perfusion study in rats [33], P e f f , r a t was lower at a higher concentration of metformin …
intestinal perfusion study in rats [33], P e f f , r a t was lower at a higher concentration of metformin …
Improvement of intestinal transport, absorption and anti-diabetic efficacy of berberine by using Gelucire44/14: in vitro, in situ and in vivo studies
J Sun, H Bao, Y Peng, H Zhang, Y Sun, J Qi… - International Journal of …, 2018 - Elsevier
… in intestinal perfusion nor changed the morphology of the rat … transport across the rat intestinal
membrane by using an in … 5.0%, v/v) group, and metformin (200 mg/kg) group were treated …
membrane by using an in … 5.0%, v/v) group, and metformin (200 mg/kg) group were treated …
In situ intestinal perfusion in rodents: future perspectives for application on absorption studies and classification of drugs
T Marinho Dezani, A Bersani Dezani… - Mini Reviews in …, 2017 - ingentaconnect.com
… for intestinal permeability: SPIP and Doluisio perfusion method. The permeability in rats was
… In the triple singlepass intestinal perfusion (TSPIP), three portions of the intestine can be …
… In the triple singlepass intestinal perfusion (TSPIP), three portions of the intestine can be …